Cholinesterase inhibitors for mild cognitive impairment

Cholinesterase inhibitors should not be prescribed for mild cognitive impairment.

Cholinesterase inhibitors in vascular cognitive impairment.

Vascular Cognitive Impairment (VCI) includes vascular dementia, mixed dementia (Alzheimer’s disease [AD] with cerebrovascular disease), and vascular mild cognitive impairment, and it is a common cause of cognitive dysfunction1. Some may even contend that it is the most common cause of cognitive impairment. This is based principally on clinicopathological data showing that most aged individuals ...

Cholinesterase Inhibitors in Mild Cognitive Impairment: A Systematic Review of Randomised Trials

BACKGROUND Mild cognitive impairment (MCI) refers to a transitional zone between normal ageing and dementia. Despite the uncertainty regarding the definition of MCI as a clinical entity, clinical trials have been conducted in the attempt to study the role of cholinesterase inhibitors (ChEIs) currently approved for symptomatic treatment of mild to moderate Alzheimer disease (AD), in preventing p...

ACP Journal Club. Review: cholinesterase inhibitors do not reduce progression to dementia from mild cognitive impairment.

Review scope Included studies compared ChEIs (donepezil, rivastigmine, galantamine, or tacrine) with placebo for ≥ 1 month in adults with mild cognitive impairment (as defined by each study but including subjective memory complaint and relatively preserved daily functioning). Primary outcomes were progression to dementia, which included Alzheimer disease (National Institute of Neurological and ...

Mild Cognitive Impairment.

PURPOSE OF REVIEW As individuals age, the quality of cognitive function becomes an increasingly important topic. The concept of mild cognitive impairment (MCI) has evolved over the past 2 decades to represent a state of cognitive function between that seen in normal aging and dementia. As such, it is important for health care providers to be aware of the condition and place it in the appropriat...